Insights from Microscopy Experts

What We Learned from Meeting with Imaging Scientists & Imaging Software Fellows

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A color-coded 3D projection of computationally separated cells from the eye of a developing zebrafish embryo as imaged using the lattice light-sheet microscopy with adaptive optics. Photo provided by CZI Imaging Scientist Srigokul Upadhyayula of UC Berkeley.

Three challenges facing the microscopy field today

1. Many of the new microscopes, particularly when in the pre-commercial stage, require special expertise to assemble and even to operate.

2. New imaging innovations spread slowly throughout the scientific community because commercialization is slow, or may not happen at all.

3. The biological community struggles with visualizing, analyzing, storing, and sharing the large volumes of imaging data that modern microscopy can generate.

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CZI’s Imaging Software Fellows, from left: Allen Goodman of the Broad Institute of MIT and Harvard, Juan Nunez-Iglesias, of Monash University in Australia, and Curtis T. Rueden of the University of Wisconsin-Madison.

Learnings from our initial meeting

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CZI Imaging Scientists and Imaging Software Fellows grantees at their first meeting together.

1. The field could greatly benefit from a shadowing program.

CZI Imaging Scientist Michelle Itano participates in a job shadowing program.

2. Supporting robust computational tools is essential to move the field forward.

3. More support for open source software is needed.

4. Microscopy courses that “train the trainers” would have the highest impact.

Where are we headed?

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CZI Imaging Scientist Caterina Strambio-De-Castillia of the University of Massachusetts Medical School writes on a blackboard.

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