Imaging the Future: How Researchers are Advancing Imaging Science

Open Dissemination of Novel Imaging Tools for the Research Community

Uri Manor, Salk Institute for Biological Studies

Left: Image of the actin cytoskeleton, the “muscle” of the cell, which allows cells to move and divide, and mitochondria, one of the most important organelles in the cell. Right: The inner ear cells of a mouse. Photos by Uri Manor, Salk Institute for Biological Studies, Waitt Advanced Biophotonics Core.

“As an imaging scientist, I am delighted by the beautiful structures of the inner ear stereocilia. As a hearing impaired person, I am passionate about turning our research into something that can be used to treat this disability.” -Uri Manor

Widening the Lens: Illuminating Talent with Immersive Microscopy Education

Bryan Millis, Vanderbilt University

Video of live kidney cells by biologist and engineer Bryan Millis, Vanderbilt University, Cell Imaging Shared Resource and the Vanderbilt Biophotonics Center.

Democratizing Imaging for Infectious Disease Research in Africa

Caron Jacobs, University of Cape Town

This superresolution image shows receptor molecules on the surface of a T-cell (cyan) and HIV particles bound to the cell membrane (magenta), allowing researchers to see how viruses impact cells. Photo by Caron Jacobs, University of Cape Town, Confocal and Light Microscope Imaging Facility.

Enabling a New Type of Microscopy for Ultradeep Imaging

Randy Bartels, Colorado State University

Photo of a canine intestine by Randy Bartels, Colorado State University.

“Optical and biomedical microscopy are undergoing a revolution. My goal is to unscramble the mysteries of light in order to illuminate the mysteries of life.” -Randy Bartels

Randy Bartels and his team at Colorado State University are working to develop new imaging technologies to help render what was previously hidden now visible to scientists.

Single-Cell Photoacoustic Molecular Imaging at Centimeter Depth

Song Hu, Washington University in St. Louis

High-resolution photoacoustic microscopy of the blood flow in a live mouse brain by Song Hu, Washington University in St. Louis.

“I decided to enter the field of imaging science to contribute to the advancement of human health through technological innovations.” -Song Hu

What if researchers could view cells deep inside the brain in real time? It could revolutionize brain research — revealing complex brain-wide interactions across neurons that drive normal behavior and that go awry in neurological and psychiatric disorders. A team of researchers at Washington University in St. Louis, led by Song Hu, is working to build a new photoacoustic imaging technology that combines light and ultrasound and would allow researchers to view live tissue deep inside the human body at the cellular level. If successful, this new technology could unlock new understanding about neuroscience.

Developing a National Center for Doctoral Training in Microscopy

Kerry Thompson, National University of Ireland Galway

Confocal fluorescence image of cells lining the womb. Image by Kerry Thompson, National University of Ireland Galway, Centre for Microscopy and Imaging.

“The inherent variety and beauty in what we do is what makes this science so relatable to the public, who often admire the artistic qualities of the images without necessarily needing to understand what is being observed.” -Kerry Thompson

Developing an Advanced Bioimaging Core in Latin America

Leonel Malacrida, Institut Pasteur de Montevideo-Universidad de la República del Uruguay

Video of a fibroblast from a mouse labeled with a membrane dye using time-resolved multiphoton microscopy by Leonel Malacrida, Institut Pasteur de Montevideo-Universidad de la República del Uruguay, Advanced Bioimaging Unit.

“I’m working to bring advanced imaging technologies and tools to my community here in Uruguay and share infrastructure and knowledge with researchers.” -Leonel Malacrida

Malacrida captured this movie of fibroblast cells, which are important for healing wounds, using time-resolved fluorescence microscopy and multiphoton excitation. He’s also building two new specialized multiphoton microscopes for deep tissue imaging in scattering samples.

Advancing Multi-Scale Imaging to Catalyze Biomedical Research

James Fitzpatrick, Washington University School of Medicine in St. Louis

Photo of fluorescence markers illuminating cells in a mouse brain by James Fitzpatrick, Washington University School of Medicine in St. Louis, Center for Cellular Imaging.

“I derive a lot of joy from developing targeted tools and workflows to help researchers in their quest to answer a specific biomedical question.” -James Fitzpatrick

Training and Mentoring Imaging Scientists and Building Imaging Communities

Claire Brown, McGill University, Advanced BioImaging Facility

TIRF microscopy imaging of paxillin-EGFP in CHO-K1 cells by Claire M. Brown, McGill University, Advanced BioImaging Facility.

Computational Microscopy with Multiple-Scattering Samples

Shwetadwip Chowdhury, University of Texas at Austin

3D tomographic rendering of embryos from the nematode worm C. elegans by Shwetadwip Chowdhury, University of Texas at Austin.

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