Open source software is the foundation of modern biomedicine. It accelerates scientific discovery by being free and accessible to the public, allowing anyone to use, adapt, and build on existing work. As part of our Open Science vision at CZI, we’re committed to supporting the creators and maintainers of critical…

Notes from the 2023 hackathon hosted by the Chan Zuckerberg Initiative — Over the last few decades, a scientific culture has emerged that defines success as publication in high-prestige journals and relies on citation-based metrics as the currency of scientific excellence. Creators of critical resources — software, data, methods, hardware — that empower scientists across the globe often struggle to demonstrate their…

In 2018, we launched the Neurodegeneration Challenge Network (NDCN) with the vision that by attracting new talent, ideas, and perspectives to the field, this network of collaborative interdisciplinary scientists would both challenge and advance our understanding of the biology underlying neurodegenerative diseases. …

For Ricky Safer, being diagnosed with a rare disease in 2003 was an isolating experience. Doctors knew little about the cause of her illness, primary sclerosing cholangitis (PSC), which afflicts the liver in 1 in 10,000 people in the United States. There was — and still is — no cure. …

Learn how CZI grantees are developing technology to revolutionize the field of imaging Cutting-edge imaging tools can help scientists around the world visualize cells, organs, and entire systems within the human body — which can lead to breakthroughs in our understanding of health and disease. …

New grants support training and resources for a global community of scientific computing practitioners — Representation from different cultures and lived experiences leads to better research outcomes for the scientific community. Despite increasing evidence that representative participation improves the overall quality of science, the field remains dominated mainly by relatively narrow demographics of participants, and significant barriers still exist for researchers based outside of North…

How researchers are navigating the challenges and promises of building single-cell catalogues to better understand disease Lisa Dratva, a doctoral student at the Wellcome Sanger Institute, studies how people’s immune systems react to COVID-19. She wants to know which T cells activate and fight the virus causing the infection. To…

Improving access to open source software tools is a cornerstone of our science work at the Chan Zuckerberg Initiative (CZI). These tools, which are built by scientific communities for scientific communities, can help accelerate the pace of scientific discovery by increasing collaboration and reproducibility. Across our different focus areas at…

By 2050, an estimated 12 million Americans will struggle with neurodegenerative diseases such as Alzheimer’s, ALS, and Parkinson’s. The Chan Zuckerberg Initiative (CZI) is bringing together researchers early in their careers and from diverse fields to develop bold new ideas to help tackle this public health crisis. As part of…